TEST YOUR KNOWLEDGE
scroll to explore
FcRn: a critical player in IgG regulation1
The neonatal Fc receptor (FcRn) is present in several cell types, including vascular endothelial cells, and is responsible for recycling all kinds of immunoglobulin G (IgG) antibodies, reducing their clearance, and prolonging their half-life.1
IgG and gMG
Pathogenic IgG autoantibodies target vital components of the neuromuscular junction (NMJ), including acetylcholine receptors (AChR), muscle-specific tyrosine kinase (MuSK), and low-density lipoprotein receptor-related protein 4 (LRP4).2
Further exploration of FcRn is warranted
In targeting the NMJ, pathogenic IgG autoantibodies disrupt neuromuscular transmission and drive the skeletal muscle weakness that defines gMG.3,4 Therefore, it may be worth exploring strategies that modulate the recycling of IgG antibodies by FcRn.1
Dive deeper into the role of IgG autoantibodies and FcRn-mediated antibody recycling in gMG
References: 1. Roopenian DC, Akilesh S. Nat Rev Immunol. 2007;7(9):715-725. doi:10.1038/nri2155 2. Gilhus NE et al. Nat Rev Neurol. 2016;12(5):259-268. doi:10.1038/nrneurol.2016.44 3. Huijbers MG et al. J Intern Med. 2014;275(1):12-26. doi:10.1111/joim.12163 4. Gilhus NE. N Engl J Med. 2016;375(26):2570-2581. doi:10.1056/NEJMra1602678
FOR US PHYSICIANS ONLY.
© 2021 argenx US-NON-20-00016v2 09/2021.
All Rights Reserved.